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Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breast

Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 621-628 doi: 10.1007/s11684-020-0738-0

Abstract: Multi-gene assays have emerged as crucial tools for risk stratification in early-stage breast cancer.This study aimed to evaluate the prognostic significance of the 21-gene recurrence score (RS) in Chinese

Keywords： early breast cancer     21-gene assay     recurrence score     prognosis    

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Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 148-152 doi: 10.1007/s11684-009-0032-7

Abstract: To investigate the regulation of tumor suppressor XAF1 gene expression in digestive system cancers, westudied XAF1 gene promoter transcription activity and mRNA level in digestive system cancer cell linesand human embryonic kidney 293 cells [HEK293 cells]) as controls. 1395-bp-promoter fragment of XAF1 geneThe promoter transcription activity was determined by dual-luciferase report assay, and enhanced greenThe dual-luciferase reporter assay showed that the promoter transcription activity in digestive system

Keywords： gene     X-linked inhibitor of apoptosis protein associated factor-1 (XAF1)     promoter     transcription regulation    

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significance of CD34+CD117dim/CD34+CD117bri myeloblast-associated geneexpression in t(8;21) acute myeloid leukemia

Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 608-620 doi: 10.1007/s11684-021-0836-7

Abstract: Here, we examined the impact of CD34 CD117 /CD34 CD117 myeloblast-associated gene expression on t(8;21) AML clinical prognosis.In this study, 85 patients with t(8;21) AML were enrolled.Associations between gene expression and clinical outcomes were determined using Cox regression modelsIdentifying the clinical relevance of CD34 CD117 /CD34 CD117 myeloblast-associated gene expression may

Keywords： t(8     21)(q22     q22) AML     CD34+CD117dim/ CD34+CD117bri cell population     gene expression     prognosis    

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The Potential Role of Powdery Mildew-Resistance Gene Pm40 in Chinese Wheat-Breeding Programs inthe Post-Pm21 Era Perspective

Shengwen Tang,Yuting Hu,Shengfu Zhong,Peigao Luo

Engineering 2018, Volume 4, Issue 4,   Pages 500-506 doi: 10.1016/j.eng.2018.06.004

Abstract: Powdery mildew-resistance (Pm) gene Pm21 was first transferred into wheat in the 1980sRecently, new Bgt isolates that are virulent to Pm21 have been identified in some wheat fields, indicating that wheat breeders should be aware of the risk of deploying Pm21, although pathologicalbelieve that Pm40 will play a role in powdery mildew-resistance wheat breeding after Pm21In addition, both Pm21 and Pm40 were derived from alien species, suggesting that the

Keywords： Wheat     Powdery mildew     Pm21     Pm40     Alien species     Native resistance    

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Biosensor-based assay of exosome biomarker for early diagnosis of cancer

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 157-175 doi: 10.1007/s11684-021-0884-z

Abstract: In this review, the latest advances of biosensors regarding the assay of exosomes were summarized, and

Keywords： biosensor     exosome     cancer diagnosis    

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Half-Life Extension Enhances Drug Efficacy in Adeno-Associated Virus Delivered Gene Therapy Article

Huifang Wu, Dan Hu, Quanxiao Li, Chunyu Wang, Xiaoyi Zhu, Wei Li, Binfan Chen, Ping Ji, Keke Huang, Ailing Huang, Jinghe Huang, Dimiter S. Dimitrov, Yanling Wu, Tianlei Ying

Engineering 2023, Volume 21, Issue 2,   Pages 203-213 doi: 10.1016/j.eng.2022.02.009

Abstract: However, the impact of drug half-life on gene therapy, which inherently provides long-lasting production(IgG1) fragment crystallizable (sFc) or Fc region of IgG in adeno-associated virus (AAV)-delivered gene(FGF21) significantly increased their concentrations in the bloodstream circulation.Moreover, the half-life extension of AAV-delivered FGF21 resulted in a remarkable reduction in liverThese results demonstrate the therapeutic potential of gene therapy with prolonged drug half-life in

Keywords： Gene therapy     Adeno-associated virus     Half-life     Fibroblast growth factor 21     Type 2 diabetes mellitus    

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Orienting the Forest Remote Sensing of the 21st Century in China

Zhao Xianwen

Strategic Study of CAE 1999, Volume 1, Issue 3,   Pages 16-21

Abstract:

In the light of the mentioned above, the forest remote sensing perspective of the 21 st century

Keywords： forestry     remote sensing     developing of sustainable forestry     forestry towards the 21 st century    

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Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

Huating Li, Jing Zhang, Weiping Jia

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 25-30 doi: 10.1007/s11684-013-0244-8

Abstract:

Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor family.It is demonstrated that FGF21 acts on multiple tissue to coordinate carbohydrate and lipid metabolismMoreover, FGF21 also plays important roles in some physiological processes, such as fasting and feedingClinical relevance of FGF21 in humans is still unclear, and the basis and consequences of increased FGF21This article concentrates on recent advances in our understanding of FGF21.

Keywords： FGF21     metabolism     pharmacology     physiology     clinical relevance    

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An Opinion on the Development of Oil and Gas Industry in the 21st Century

Chen Junwu

Strategic Study of CAE 2000, Volume 2, Issue 4,   Pages 21-24

Abstract:

The speed of international social-economic development closely depends upon the growth of world energy consumption, which in turn has to meet the stringent environmental protection policy that controls the total amount of greenhouse gas released to the atmosphere in the burning of fuel. In order to achieve the sustainable development of all nations, it is advisable to give an outlook to the future situation of world oil and gas industry as the representatives of the non-regenerable energy resources. This paper presents an opinion on the future development of oil and gas industry based on limited data published in literature together with controversial forecasts by different authors and covers four subjects： (1) the demand and supply of oil and gas in the new century; (2) the specifications of oil products to meet the environmental regulations; (3) the role of unconventional oil in the energy industry and (4) the brilliant future of natural gas.

Keywords： 21st centurey     petroleum     natural gas     oil and gas industry    

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Clinical outcomes of ATP-tumor chemosensitivity assay directed chemotherapy in hepatocellular carcinoma

RAO Rongsheng, CHEN Wenxue, ZHOU Xinwen, ZHOU Zheng, LI Xiaojun, ZENG Zhiping

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 157-160 doi: 10.1007/s11684-007-0029-z

Abstract: This study aims to investigate the clinical response of ATP tumor chemosensitivity assay (ATP-TCA) directedThis tissue was put through the assay to determine chemosensitivity.
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Science and Technology in Human's Living and Survival in the 21st Century

Jiang Zhenghua

Strategic Study of CAE 2002, Volume 4, Issue 4,   Pages 1-11

Abstract:

This article, from the angle of management, reviews the world history over the past century, studies the prospective progress in the new century, and discusses ways for promoting world peace and cooperation and realizing common development.

Keywords： 21st century     progress in science and technology     human's living and survival    

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Digital manufacturing—the development direction of the manufacturing technology in the 21st century

XIONG You-lun, YIN Zhou-ping

Frontiers of Mechanical Engineering 2006, Volume 1, Issue 2,   Pages 125-130 doi: 10.1007/s11465-006-0021-3

Abstract: After introducing the concepts of digital manufacturing technology, the discipline framework of digital manufacturing is presented in the paper by discussing its basic concept, theory foundation, key technology and scientific problems in detail. As the core of the advanced manufacturing technology, digital manufacturing is gradually becoming the main manufacturing technology of the twenty-first century. Firstly, the main features of digital manufacturing are indicated and its key supporting technologies are investigated by grouping them into four levels related to product development, numerical control, production management, and enterprise collaboration, respectively. Moreover, the existing problems in the research on the multi-discipline theory foundation of digital manufacturing such as manufacturing informatics, computational manufacturing, and manufacturing intelligence, are also indicated. Then, the core scientific problems of digital manufacturing are discussed in depth, which focuses on digitization of manufacturing information, modeling of manufacturing constraints, high-speed and high-precision numerical control theory, and Internet-based collaboration and integration. Lastly, the development trends and application perspectives of digital manufacturing are concluded.

Keywords： development     foundation     multi-discipline     scientific     supporting    

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An extraction- assay system: Evaluation on flavonols in plant resistance to Pb and Cd by supercritical

Xu Zhang, Huanhuan Yang, Xinlei Wang, Wen Song, Zhaojie Cui

Frontiers of Environmental Science & Engineering 2018, Volume 12, Issue 4, doi: 10.1007/s11783-018-1059-2

Abstract:

Gene expression analysis shows consistent regularity

Keywords： Flavonols     Heavy metal     Supercritical carbon dioxide extraction (SFE)     GC     Plant resistance    

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The Challenge of Computing and Information Technology in the 21st Century

Wm. A. Wulf

Strategic Study of CAE 2000, Volume 2, Issue 10,   Pages 9-12

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Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Strategic Study of CAE 2000, Volume 2, Issue 11,   Pages 1-11

Abstract:

In this paper, the study on family collection, gene mapping, gene identification and gene functiont (1; 3) (q44; p11) associated with nasopharyngeal cancer was found in 1975 at first, and human TDF geneIn 1998, GJB3, a human genetic neurological deafness gene, was identified using a novel strategy of “Gene Family-Candidate Disease Gene Cloning”，and the paper was published in Nature Geneticswas also cloned from gene function study.

Keywords： genetic disease     gene mapping and cloning     gene familiy-candidate disease gene cloning     genome wide scan     gene function study    

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Title Author Date Type Operation

Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breast

Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen

Journal Article

Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Journal Article

significance of CD34+CD117dim/CD34+CD117bri myeloblast-associated geneexpression in t(8;21) acute myeloid leukemia

Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang

Journal Article

The Potential Role of Powdery Mildew-Resistance Gene Pm40 in Chinese Wheat-Breeding Programs inthe Post-Pm21 Era

Shengwen Tang,Yuting Hu,Shengfu Zhong,Peigao Luo

Journal Article

Biosensor-based assay of exosome biomarker for early diagnosis of cancer

Journal Article

Half-Life Extension Enhances Drug Efficacy in Adeno-Associated Virus Delivered Gene Therapy

Huifang Wu, Dan Hu, Quanxiao Li, Chunyu Wang, Xiaoyi Zhu, Wei Li, Binfan Chen, Ping Ji, Keke Huang, Ailing Huang, Jinghe Huang, Dimiter S. Dimitrov, Yanling Wu, Tianlei Ying

Journal Article

Orienting the Forest Remote Sensing of the 21st Century in China

Zhao Xianwen

Journal Article

Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

Huating Li, Jing Zhang, Weiping Jia

Journal Article

An Opinion on the Development of Oil and Gas Industry in the 21st Century

Chen Junwu

Journal Article

Clinical outcomes of ATP-tumor chemosensitivity assay directed chemotherapy in hepatocellular carcinoma

RAO Rongsheng, CHEN Wenxue, ZHOU Xinwen, ZHOU Zheng, LI Xiaojun, ZENG Zhiping

Journal Article

Science and Technology in Human's Living and Survival in the 21st Century

Jiang Zhenghua

Journal Article

Digital manufacturing—the development direction of the manufacturing technology in the 21st century

XIONG You-lun, YIN Zhou-ping

Journal Article

An extraction- assay system: Evaluation on flavonols in plant resistance to Pb and Cd by supercritical

Xu Zhang, Huanhuan Yang, Xinlei Wang, Wen Song, Zhaojie Cui

Journal Article

The Challenge of Computing and Information Technology in the 21st Century

Wm. A. Wulf

Journal Article

Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Journal Article